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Alosetron occurs as 5-HT₃ antagonist used for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women exclusively. It was withdrawn from either a market inside 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, however was reintroduced around 2002 with availability & apply restricted. These are presently marketed by GlaxoSmithKline under the brand name Lotronex.

Mode of action
Alosetron, when existence the Fin-HT_Three antagonist such as ondansetron, is not an antiemetic drug. Alosetron has an antagonist action on the Phoebe-HT_Three receptors of the enteric nervous system of the gastrointestinal tract.

Serious adverse effects
Alosetron was withdrawn inside 2000 following the association of alosetron sustaining good life-threatening gi adverse results.

A accumulative incidence of ischaemic colitis was 2 around M, spell good complications arising from either constipation (obstruction, perforation, impaction, toxic megacolon, secondary colonic ischaemia, death) was 1 inside Thou (GlaxoSmithKline, 2002).

Lotronex
Full prescribing information from RxList.

Lotronex Information - FDA
Includes information for patients and care givers with links to current (re-released)product information and information about the previous withdrawal from the market in 2000.

Lotronex (Alosetron HCI) - GSK
Official pharmaceutical website with information for patients and care givers.